Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 5/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16032074 | 0.90 | HAO1 (0.43) | PTGESHAO1FFAR1GRM5EPHX2 | |
| SCHEMBL237114 | 0.86 | PTGES (0.37) | PTGESHAO1FFAR1FFAR4EPHX2 | |
| SCHEMBL3837431 | 0.85 | SLC6A3 (0.34) | PTGESGRM5EPHX2ALOX5KDM4E | |
| SCHEMBL237238 | 0.84 | DDB1 (0.40) | PTGESHAO1GRM5 | |
| SCHEMBL234717 | 0.84 | EPHX1 (0.39) | PTGESHAO1FFAR1FFAR4GRM5 | |
| SCHEMBL236453 | 0.84 | EPHX1 (0.39) | PTGESHAO1FFAR1FFAR4GRM5 | |
| SCHEMBL233588 | 0.83 | HAO1 (0.37) | PTGESHAO1FFAR1FFAR4 | |
| SCHEMBL3839542 | 0.83 | PTPN11 (0.41) | PTGESFFAR1GRM5EPHX2ALOX5 | |
| SCHEMBL236160 | 0.82 | PTGES (0.39) | PTGESHAO1FFAR1GRM5EPHX2 | |
| SCHEMBL233144 | 0.82 | HAO1 (0.38) | PTGESHAO1FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541769-A | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC | 2016-05-04 | — | — | CN | disclosed |
| CN-103664637-B | Be used for the treatment of ophthalmic diseases and disorderly alkynyl phenyl derivative compounds | ACUCELA INC. (US) | 2016-02-03 | — | — | CN | disclosed |