Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15880899 | 0.84 | MEN1 (0.46) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL17669635 | 0.79 | CCR1 (0.55) | LMNACYP3A4KMT2AKDM4EACHE | |
| SCHEMBL30943495 | 0.78 | CCR1 (0.59) | CYP3A4HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL7856828 | 0.78 | CCR1 (0.59) | CYP3A4HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL25984345 | 0.75 | PROKR1 (0.48) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL28025233 | 0.74 | HDAC4 (0.39) | LMNACYP3A4HDAC4KMT2AKDM4E | |
| SCHEMBL9670309 | 0.74 | LMNA (0.47) | LMNACYP3A4KMT2AKDM4EACHE | |
| SCHEMBL7674985 | 0.74 | LMNA (0.52) | LMNACYP3A4KDM4EACHEALDH1A1 | |
| SCHEMBL25348842 | 0.73 | LMNA (0.46) | LMNACYP3A4KMT2AKDM4EACHE | |
| Hydrochloric Acid SCHEMBL10529996 | 0.73 | LMNA (0.50) | LMNACYP3A4KDM4EACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105452233-A | Piperidine and azepane derivatives as prokineticin receptor modulators | TAKEDA PHARMACEUTICALS CO | 2016-03-30 | — | — | CN | disclosed |