Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 2/20 | 0.56 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.50 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14073817 | 0.86 | PLOD2 (0.59) | PLOD2F7F3SARM1SIRT2 | |
| Nicotinoylalaninenal SCHEMBL8439392 | 0.82 | PLOD2 (0.58) | PLOD2F7F3SARM1SIRT2 | |
| SCHEMBL27512365 | 0.82 | PLOD2 (0.58) | PLOD2F7F3SARM1SIRT2 | |
| Nicotinoylalaninenal SCHEMBL20561157 | 0.82 | PLOD2 (0.58) | PLOD2F7F3SARM1SIRT2 | |
| SCHEMBL20561378 | 0.81 | PLOD2 (0.50) | PLOD2F7F3SARM1SIRT2 | |
| SCHEMBL27728362 | 0.81 | PLOD2 (0.57) | PLOD2F7F3SARM1SIRT2 | |
| SCHEMBL6199618 | 0.81 | PLOD2 (0.53) | PLOD2F7F3SARM1SIRT2 | |
| SCHEMBL27805774 | 0.80 | F7 (0.44) | PLOD2F7F3SARM1SIRT2 | |
| SCHEMBL28048461 | 0.80 | F7 (0.44) | PLOD2F7F3SARM1SIRT2 | |
| SCHEMBL10050050 | 0.80 | PLOD2 (0.51) | PLOD2F7F3SARM1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103930421-B | 4,5,6,7-tetrahydrochysene-1H-pyrazolo [4,3-c] pyridine that replaces, they are as the purposes of medicine and the pharmaceutical preparation that comprises them | 赛诺菲 | 2016-06-29 | — | — | CN | disclosed |