Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | FADS1 | O60427 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL637576 | 0.78 | ALDH1A1 (0.53) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL2941784 | 0.77 | ALDH1A1 (0.52) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL9312422 | 0.76 | CES2 (0.60) | MAPTGAAALDH1A1ALOX15NPC1 | |
| SCHEMBL30682655 | 0.76 | CES2 (0.60) | MAPTGAAALDH1A1ALOX15NPC1 | |
| SCHEMBL9471207 | 0.75 | ALDH1A1 (0.41) | MAPTGAAALDH1A1KDM4EPTGS1 | |
| SCHEMBL10885871 | 0.75 | MAPT (0.56) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL31521462 | 0.74 | CES2 (0.58) | ALDH1A1TSHRHPGDPOLBMEN1 | |
| SCHEMBL32665936 | 0.74 | HPGD (0.46) | ALDH1A1HSD17B10KDM4ENPC1RAB9A | |
| SCHEMBL21761714 | 0.74 | MAPT (0.41) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL112507 | 0.74 | MAPT (0.74) | MAPTGAAALDH1A1HSD17B10CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105358151-B | For treating the compound of Duchenne-Arandisease | 豪夫迈·罗氏有限公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-105358151-A | Compounds for treating spinal muscular atrophy | HOFFMANN LA ROCHE | 2016-02-24 | — | — | CN | disclosed |