Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.78 |
| ▸ | JAK3 | P52333 | 4/20 | 0.74 |
| ▸ | CTSC | P53634 | 4/20 | 0.64 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | BLK | P51451 | 2/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
| ▸ | ITK | Q08881 | 1/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.61 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.61 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.61 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.61 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28452560 | 0.96 | EGFR (0.73) | EGFRJAK3CTSCFLT3BLK | |
| SCHEMBL28053996 | 0.92 | ALK (0.75) | EGFRJAK3ALKGAKPTK2 | |
| SCHEMBL28447722 | 0.91 | EGFR (0.78) | EGFRJAK3ALK | |
| SCHEMBL28053986 | 0.91 | EGFR (0.80) | EGFRJAK3CTSCFLT3BLK | |
| SCHEMBL28053999 | 0.90 | EGFR (0.65) | EGFRJAK3CTSCFLT3BLK | |
| SCHEMBL17059644 | 0.88 | EGFR (1.00) | EGFRJAK3CTSCFLT3BLK | |
| SCHEMBL28053891 | 0.87 | JAK3 (0.77) | EGFRJAK3CTSCFLT3BLK | |
| SCHEMBL17209827 | 0.85 | JAK3 (1.00) | EGFRJAK3FLT3BLKJAK2 | |
| SCHEMBL28053991 | 0.84 | JAK3 (0.73) | EGFRJAK3CTSCFLT3BLK | |
| SCHEMBL28915867 | 0.83 | EGFR (0.75) | EGFRJAK3ALKGAKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-B | Substituted aminopyrimidine derivative and preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-105384694-A | Substituted aminopyrimidine derivative, preparation method therefor and pharmaceutical application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |