Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Perospirone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.89 |
| ▸ | LMNA | P02545 | 1/20 | 0.89 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.89 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.89 |
| ▸ | DRD1 | P21728 | 1/20 | 0.89 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.89 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.89 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.89 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.89 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.89 |
| ▸ | DRD3 | P35462 | 1/20 | 0.89 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.89 |
| ▸ | DRD2 | P14416 | 3/20 | 0.66 |
| ▸ | HTR2A | P28223 | 3/20 | 0.66 |
| ▸ | HTR7 | P34969 | 2/20 | 0.66 |
| ▸ | HTR6 | P50406 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perospirone SCHEMBL29846330 | 0.95 | HTR1A (0.98) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| Perospirone SCHEMBL1155757 | 0.95 | HTR1A (0.98) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| Perospirone SCHEMBL5435087 | 0.94 | HTR1A (0.96) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| Perospirone SCHEMBL1865565 | 0.94 | HTR1A (0.96) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| Perospirone SCHEMBL30061058 | 0.94 | HTR1A (1.00) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| Perospirone SCHEMBL120579 | 0.94 | HTR1A (1.00) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| Perospirone SCHEMBL6691734 | 0.94 | HTR1A (1.00) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| Perospirone SCHEMBL28506465 | 0.93 | HTR1A (0.98) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| Perospirone SCHEMBL1651000 | 0.92 | HTR1A (0.96) | HTR1ALMNACHRM2ADRA2ACHRM1 | |
| SCHEMBL7283429 | 0.85 | HTR1A (0.79) | HTR1ALMNACHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103393614-B | A kind of Perospirone Hydrochloride slow releasing preparation and preparation method | LIVZON GROUP LIVZON PHARMACEUTICAL FACTORY (CN) | 2016-01-27 | — | — | CN | disclosed |