Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28055093 | 0.97 | PLA2G10 (0.42) | PLA2G10PLA2G5FAAHALDH1A1KDM4E | |
| SCHEMBL27894045 | 0.94 | PLA2G10 (0.43) | PLA2G10PLA2G5FAAHMEN1KMT2A | |
| SCHEMBL28055160 | 0.89 | TSHR (0.42) | ALDH1A1KDM4EMEN1LMNACYP3A4 | |
| SCHEMBL1586934 | 0.82 | PLA2G10 (0.39) | PLA2G10PLA2G5 | |
| SCHEMBL1554996 | 0.82 | PLA2G10 (0.39) | PLA2G10PLA2G5 | |
| SCHEMBL27894049 | 0.80 | PKM (0.38) | PLA2G10PLA2G5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1556365 | 0.78 | PLA2G10 (0.40) | PLA2G10PLA2G5 | |
| SCHEMBL1555754 | 0.78 | PLA2G10 (0.40) | PLA2G10PLA2G5 | |
| SCHEMBL1586781 | 0.75 | PDK1 (0.43) | ALDH1A1 | |
| SCHEMBL1555362 | 0.75 | PDK1 (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102762541-B | Diaza derivatives as modulators of chemokine receptors | HOFFMAN-LA ROCHE LTD. (CH) | 2016-03-16 | — | — | CN | disclosed |
| CN-102762541-A | Diaza derivatives as modulators of chemokine receptors | HOFFMANN LA ROCHE | 2012-10-31 | — | — | CN | disclosed |