Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Benzenesulfonamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 8/20 | 0.67 |
| ▸ | CA2 | P00918 | 8/20 | 0.67 |
| ▸ | CA9 | Q16790 | 8/20 | 0.67 |
| ▸ | CA12 | O43570 | 7/20 | 0.67 |
| ▸ | CA3 | P07451 | 2/20 | 0.67 |
| ▸ | CA6 | P23280 | 2/20 | 0.67 |
| ▸ | CA5A | P35218 | 2/20 | 0.67 |
| ▸ | CA7 | P43166 | 2/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.67 |
| ▸ | CA4 | P22748 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.59 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Toluenesulfonamide SCHEMBL7021094 | 0.92 | CA2 (0.78) | CA1CA2CA9CA12CA3 | |
| SCHEMBL932442 | 0.90 | SMN1; SMN2 (0.73) | CA1CA2CA9CA12CA3 | |
| SCHEMBL13836876 | 0.90 | SMN1; SMN2 (0.73) | CA1CA2CA9CA12CA3 | |
| P-Toluenesulfonamide SCHEMBL5691991 | 0.90 | CA2 (0.82) | CA1CA2CA9CA12CA3 | |
| Water SCHEMBL14660542 | 0.88 | SMN1; SMN2 (0.70) | CA1CA2CA9CA12CA3 | |
| Benzenesulfonamide SCHEMBL10396798 | 0.88 | CA2 (0.76) | CA1CA2CA9CA12CA3 | |
| Sulfuric Acid SCHEMBL14660473 | 0.86 | SMN1; SMN2 (0.67) | CA1CA2CA9CA12CA3 | |
| Toluene SCHEMBL180606 | 0.86 | SMN1; SMN2 (0.65) | CA1CA2CA9CA12CA3 | |
| Benzene SCHEMBL5085625 | 0.86 | SMN1; SMN2 (0.64) | CA1CA2CA9CA12CA3 | |
| Toluene SCHEMBL2419102 | 0.84 | SMN1; SMN2 (0.62) | CA1CA2CA9CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105418599-A | New salt and medical use | PFIZER LTD | 2016-03-23 | — | — | CN | claimed |
| CN-105418599-A | New salt and medical use | PFIZER LTD | 2016-03-23 | — | — | CN | disclosed |