SCHEMBL28055407

SCHEMBL28055407

c1c[nH]nn1.c1cnc2cncnc2c1

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.38
ALDH1A1 P00352 1/20 0.33
RPS6KA5 O75582 2/20 0.33
KDM4E B2RXH2 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28022074 0.86 ALDH1A1 (0.43) ALDH1A1KDM4EMAPT
SCHEMBL51486 0.82 EGFR (0.52) EGFRALDH1A1RPS6KA5KDM4EMAPT
SCHEMBL29367065 0.82 EGFR (0.52) EGFRALDH1A1RPS6KA5KDM4EMAPT
SCHEMBL28742280 0.82 EGFR (0.52) EGFRALDH1A1RPS6KA5KDM4EMAPT
Quinazoline SCHEMBL6372936 0.81 EGFR (0.65) EGFRALDH1A1
SCHEMBL29188217 0.80 EGFR (0.50) EGFRALDH1A1RPS6KA5KDM4EMAPT
Hydrochloric Acid SCHEMBL30980980 0.80 EGFR (0.50) EGFRALDH1A1RPS6KA5KDM4EMAPT
Hydrochloric Acid SCHEMBL22289522 0.80 EGFR (0.50) EGFRALDH1A1RPS6KA5KDM4EMAPT
Pyrrole SCHEMBL82535 0.80 EGFR (0.42) EGFRALDH1A1RPS6KA5KDM4EMAPT
Quinoxaline SCHEMBL3988599 0.79 ALDH1A1 (0.38) ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105418638-B With terminal alkyne, two bromoalkanes, CO2The method that thick triazole compound is synthesized with sodium azide 广西师范大学 2018-01-19 CN disclosed
CN-105418638-A Method for synthesizing condensed triazole compound with terminal alkyne, dibromo alkane, CO2 and sodium azide UNIV GUANGXI NORMAL 2016-03-23 CN disclosed