Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13472107 | 0.80 | SMN1; SMN2 (0.54) | RAF1NPC1RAB9ASMN1; SMN2CYP17A1 | |
| SCHEMBL30298038 | 0.79 | CACNA1G (0.64) | RAF1NPC1RAB9ASMN1; SMN2CACNA1G | |
| SCHEMBL10241117 | 0.78 | EPHX2 (0.55) | RAF1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6296539 | 0.78 | GSK3B (0.39) | SMN1; SMN2CYP17A1ALDH1A1CYP2C9GSK3B | |
| SCHEMBL19937659 | 0.77 | RAF1 (0.49) | RAF1CYP17A1GSK3BDYRK1APCSK9 | |
| SCHEMBL28542105 | 0.74 | GSK3B (0.39) | CYP17A1KMT2AGSK3BDYRK1A | |
| SCHEMBL31691335 | 0.73 | CACNA1G (0.39) | RAF1NPC1RAB9ASMN1; SMN2CACNA1G | |
| SCHEMBL31691255 | 0.73 | KMT2A (0.41) | RAF1NPC1RAB9ASMN1; SMN2CACNA1G | |
| SCHEMBL29394473 | 0.73 | LCK (0.47) | NPC1RAB9ASMN1; SMN2POLBKMT2A | |
| SCHEMBL15165775 | 0.72 | SIRT1 (0.49) | NPC1RAB9ASMN1; SMN2CACNA1IALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110156772-A | Heterocyclic compound, application thereof and pharmaceutical composition containing same | 苏州信诺维医药科技有限公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-105524058-B | Pyrazolo [1,5 a] pyridine compounds and their and its application | 广州艾格生物科技有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105524058-A | Pyrazolo[1, 5-a]pyridine compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2016-04-27 | — | — | CN | disclosed |