Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657010 | 0.84 | MAOA (0.43) | EGLN1MAOALCKSCN9AMAPT | |
| SCHEMBL1656086 | 0.84 | HTT (0.41) | EGLN1LCKKDM4EMAPTLMNA | |
| SCHEMBL1658690 | 0.81 | EGLN1 (0.47) | EGLN1KDM4EMEN1KMT2A | |
| SCHEMBL1656353 | 0.81 | ESR1 (0.42) | EGLN1LCKMAPTMEN1KMT2A | |
| SCHEMBL1656615 | 0.79 | MTNR1B (0.45) | KDM4EMAPTLMNAPOLBNPSR1 | |
| SCHEMBL31225053 | 0.75 | NR4A2 (0.42) | EGLN1LCKKDM4ENPSR1HIF1A | |
| SCHEMBL28832562 | 0.74 | EGLN1 (0.48) | EGLN1HIF1A | |
| SCHEMBL23580382 | 0.74 | NR4A2 (0.43) | EGLN1LCKKDM4EMAPTPOLB | |
| SCHEMBL1656146 | 0.74 | EGLN1 (0.60) | EGLN1LCKKDM4EMAPTLMNA | |
| SCHEMBL31017018 | 0.74 | EGLN1 (0.41) | EGLN1LCKKDM4ENPSR1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103382216-B | Make the Cyanoisoquinoline compound that hypoxia inducible factor (HIF) is stable | FIBROGEN INC. (US) | 2016-04-20 | — | — | CN | disclosed |