Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16412236 | 0.82 | KCNJ1 (0.44) | KCNJ1KCNH2MAPTAHRALDH1A1 | |
| SCHEMBL3941218 | 0.78 | GLRA3 (0.42) | KCNJ1KCNH2MAPTAHRALDH1A1 | |
| SCHEMBL5826251 | 0.78 | KCNJ1 (0.42) | KCNJ1KCNH2MAPTAHRALDH1A1 | |
| SCHEMBL4649622 | 0.77 | NPC1 (0.57) | KCNJ1KCNH2MAPTALDH1A1MEN1 | |
| SCHEMBL19026582 | 0.76 | CYP19A1 (0.68) | MAPTALDH1A1MEN1KMT2ACYP19A1 | |
| SCHEMBL984873 | 0.76 | KCNJ1 (0.67) | KCNJ1KCNH2MAPTALDH1A1MEN1 | |
| SCHEMBL18731512 | 0.75 | KCNJ1 (0.45) | KCNJ1KCNH2MAPTAHRALDH1A1 | |
| SCHEMBL2530044 | 0.74 | GLRA3 (0.62) | MAPTAHRALDH1A1MEN1POLB | |
| SCHEMBL28062313 | 0.72 | KCNJ1 (0.43) | KCNJ1KCNH2MAPTALDH1A1MEN1 | |
| SCHEMBL28056041 | 0.72 | PTPRC (0.44) | KCNJ1KCNH2MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105392788-A | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC | 2016-03-09 | — | — | CN | disclosed |