SCHEMBL28056296

SCHEMBL28056296

N#Cc1ccc(-c2cccc(-c3ccccc3)c2)cc1.O=C1C=CC=C1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 1/20 0.46
GABRA1 P14867 1/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
MARK3 P27448 1/20 0.42
GSK3A P49840 1/20 0.42
ACLY P53396 2/20 0.42
PGR P06401 2/20 0.42
TSHR P16473 1/20 0.42
PTPN5 P54829 1/20 0.41
PTGES2 Q9H7Z7 1/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP11B2 P19099 1/20 0.41
FAAH O00519 1/20 0.41
HSP90AA1 P07900 1/20 0.41
PKM P14618 1/20 0.41
HTT P42858 1/20 0.41
ATM Q13315 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28056300 0.88 ATM (0.42) KAT6AGABRA1GABRG2GABRB3GABRA5
SCHEMBL18411422 0.86 TSHR (0.56) KAT6AGABRA1GABRG2GABRB3GABRA5
SCHEMBL18411359 0.86 TSHR (0.56) KAT6AGABRA1GABRG2GABRB3GABRA5
SCHEMBL28056373 0.83 ALDH1A1 (0.43) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL22507033 0.82 MMP3 (0.56) KAT6AGABRA1GABRG2GABRB3GABRA5
SCHEMBL13682562 0.80 TSHR (0.59) KAT6AGABRA1GABRG2GABRB3GABRA5
SCHEMBL1978798 0.78 TSHR (0.68) GABRA1GABRG2GABRB3GABRA5GABRA3
Benzene SCHEMBL28680466 0.78 TSHR (0.68) GABRA1GABRG2GABRB3GABRA5GABRA3
Water SCHEMBL6336152 0.78 TSHR (0.68) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL72569 0.78 TSHR (0.68) GABRA1GABRG2GABRB3GABRA5GABRA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105504186-A Preparing method and application of 3,4-bi(4-cyanophenyl)-2,5-diphenyl phenyl grafted polysiloxane UNIV SHANDONG 2016-04-20 CN claimed
CN-105504186-A Preparing method and application of 3,4-bi(4-cyanophenyl)-2,5-diphenyl phenyl grafted polysiloxane UNIV SHANDONG 2016-04-20 CN disclosed