Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | FBP1 | P09467 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.55 |
| ▸ | TEK | Q02763 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777464 | 0.89 | EGFR (0.61) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL2203223 | 0.85 | EGFR (0.55) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL7771232 | 0.82 | MEN1 (0.70) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL1095277 | 0.80 | MAPK1 (0.61) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL7777468 | 0.79 | EGFR (0.74) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL19089515 | 0.79 | GALR2 (0.49) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL7775667 | 0.79 | EGFR (0.60) | EGFRMAPK1GRM1ERBB3 | |
| SCHEMBL19089675 | 0.78 | EGFR (0.49) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL1387327 | 0.78 | APP (0.62) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL19089519 | 0.77 | EGFR (0.59) | EGFRERBB2PDGFRBKDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105367503-A | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS INC | 2016-03-02 | — | — | CN | disclosed |