Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31459702 | 0.85 | ALDH1A1 (0.50) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL17940 | 0.81 | PKM (0.49) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL16863576 | 0.81 | GAA (0.52) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL27787731 | 0.81 | PKM (0.51) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18510 | 0.80 | PKM (0.54) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL16690902 | 0.80 | PKM (0.50) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL24571057 | 0.78 | PKM (0.49) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL31564889 | 0.77 | PKM (0.40) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18120300 | 0.75 | PKM (0.47) | PKMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL17894247 | 0.74 | ALDH1A1 (0.46) | PKMNPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105452241-B | Carboxamides derivatives of ((base of pyrimidine 4) epoxide) 1H indoles 1 and application thereof | 诺华股份有限公司 | 2018-01-05 | — | — | CN | disclosed |
| CN-105452241-A | Pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide derivatives and use thereof | NOVARTIS AG | 2016-03-30 | — | — | CN | disclosed |