Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocinnamyl Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocinnamyl Alcohol SCHEMBL28225344 | 0.99 | CTSC (0.45) | CTSCKDM4EMAPTHIF1AHTR2C | |
| Proline SCHEMBL9015317 | 0.90 | CTSC (0.51) | CTSCKDM4EMAPTHIF1AHTR2C | |
| Tyrosine SCHEMBL28219554 | 0.84 | SLC7A5 (0.48) | CTSCHTR2CHTR2B | |
| Phenethylcarbamic Acid SCHEMBL28089042 | 0.82 | NPC1 (0.56) | CTSCKDM4EHTR2CHTR2BNPC1 | |
| SCHEMBL4677228 | 0.81 | EPHX2 (0.49) | CTSCMAPTHTR2CHTR2BNPC1 | |
| Proline SCHEMBL523389 | 0.81 | PRCP (0.42) | — | |
| (Chloromethyl)Benzene SCHEMBL25337720 | 0.81 | CTSC (0.49) | CTSCHTR2CHTR2BNPC1RAB9A | |
| Ethylbenzene SCHEMBL1116548 | 0.81 | CTSC (0.49) | CTSCKDM4EHTR2CHTR2BNPC1 | |
| Benzylamine SCHEMBL28304506 | 0.81 | CTSC (0.49) | CTSCHTR2CHTR2BNPC1RAB9A | |
| SCHEMBL6099087 | 0.80 | EPHX1 (0.50) | CTSCMAPTHTR2CHTR2BEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105327336-A | Chinese herbal medicine containing herba catharanthi rosei, aloes, radix zanthoxyli and mint, skin absorbable lotion and diet therapy | XIE YOUZHU | 2016-02-17 | — | — | CN | claimed |
| CN-108473484-A | Compounds useful as TRPM8 modulators | 赛诺米克斯公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-105327336-A | Chinese herbal medicine containing herba catharanthi rosei, aloes, radix zanthoxyli and mint, skin absorbable lotion and diet therapy | XIE YOUZHU | 2016-02-17 | — | — | CN | disclosed |