Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.38 |
| ▸ | LAP3 | P28838 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL10757101 | 0.92 | SLC7A5 (0.57) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Tryptophan SCHEMBL28219555 | 0.89 | KDM4E (0.51) | HTR2CHTR2B | |
| Tyrosine SCHEMBL4205061 | 0.88 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL4205059 | 0.88 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL4352800 | 0.88 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL5152642 | 0.88 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL5576441 | 0.88 | SLC7A5 (0.52) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL17728298 | 0.86 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL6665573 | 0.86 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL17728297 | 0.86 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107987126-B | The endomorphins of 4 hydrocinnamamide hydroxylatings modification are like object and its synthetic method and application | 哈尔滨工业大学 | 2018-10-02 | — | — | CN | disclosed |
| CN-107987126-A | The endomorphins of 4 hydrocinnamamide hydroxylating modifications are like thing and its synthetic method and application | 哈尔滨工业大学 | 2018-05-04 | — | — | CN | disclosed |