Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocinnamyl Alcohol SCHEMBL28058161 | 0.90 | CTSC (0.46) | CTSCHTR2CHTR2BNPC1RAB9A | |
| Phenethylcarbamic Acid SCHEMBL28089042 | 0.88 | NPC1 (0.56) | CTSCHTR2CHTR2BNPC1RAB9A | |
| Hydrocinnamyl Alcohol SCHEMBL28225344 | 0.88 | CTSC (0.45) | CTSCHTR2CHTR2BNPC1RAB9A | |
| (Chloromethyl)Benzene SCHEMBL25337720 | 0.87 | CTSC (0.49) | CTSCHTR2CHTR2BNPC1RAB9A | |
| Ethylbenzene SCHEMBL1116548 | 0.87 | CTSC (0.49) | CTSCHTR2CHTR2BNPC1RAB9A | |
| Benzylamine SCHEMBL28304506 | 0.87 | CTSC (0.49) | CTSCHTR2CHTR2BNPC1RAB9A | |
| Biphenyl SCHEMBL2308811 | 0.84 | ELANE (0.47) | CTSCHTR2CHTR2BNPC1RAB9A | |
| SCHEMBL18142154 | 0.84 | CTSC (0.49) | CTSCHTR2CHTR2BNPC1RAB9A | |
| Proline SCHEMBL16394427 | 0.84 | BLM (0.48) | CTSCRAB9AELANETSHRSCN4A | |
| SCHEMBL2089398 | 0.81 | HTR2C (0.60) | CTSCHTR2CHTR2BNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527923-A | Process for preparing enantiomerically pure diarylprolinols | BOEHRINGER INGELHEIM KG (DE) | 1996-06-18 | — | — | US | disclosed |