Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 7/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22474134 | 0.79 | PRKCI (0.47) | PRKCIGAAALDH1A1KDM4EMAPT | |
| SCHEMBL1265204 | 0.76 | PRKCI (0.36) | PRKCI | |
| SCHEMBL16427360 | 0.74 | PRKCI (0.40) | PRKCIGAACYP3A4 | |
| SCHEMBL3838657 | 0.73 | PRKCI (0.34) | PRKCIGAAALDH1A1KDM4EGLA | |
| SCHEMBL1263667 | 0.73 | PRKCI (0.36) | PRKCISKP2 | |
| SCHEMBL14302850 | 0.73 | PRKCI (0.39) | PRKCIGAAALDH1A1KDM4EMAPT | |
| SCHEMBL10979325 | 0.72 | TSHR (0.48) | GAACYP3A4ALOX15TSHRTP53 | |
| SCHEMBL28667235 | 0.72 | CYP3A4 (0.34) | GAACYP3A4AKT1SKP2KDM4E | |
| SCHEMBL11281913 | 0.71 | PRKCI (0.45) | PRKCIGAAALDH1A1KDM4EMAPT | |
| SCHEMBL18927959 | 0.71 | ALDH1A1 (0.48) | GAAALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555780-B | SYK inhibitors | 吉利德科学公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-105555780-A | Syk inhibitors | GILEAD SCIENCES INC | 2016-05-04 | — | — | CN | disclosed |