Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.64 |
| ▸ | CDK2 | P24941 | 6/20 | 0.64 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.64 |
| ▸ | CDK9 | P50750 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CDK7 | P50613 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789745 | 0.86 | CDK4 (0.62) | CDK4CDK2CCNE1CDK9CDK1 | |
| SCHEMBL28059096 | 0.79 | MAPK10 (0.68) | CDK4CDK2CCNE1CDK9CDK1 | |
| SCHEMBL4802860 | 0.78 | CDK2 (1.00) | CDK4CDK2CCNE1CDK9CDK1 | |
| Morpholine SCHEMBL28059098 | 0.76 | MAPK10 (0.46) | CDK4CDK2CCNE1CDK9CDK1 | |
| SCHEMBL28059001 | 0.74 | MAPK10 (0.61) | CDK4CDK2CCNE1CDK9CDK1 | |
| SCHEMBL28059097 | 0.72 | CDK4 (0.46) | CDK4CDK2CCNE1CDK9CDK1 | |
| SCHEMBL28059025 | 0.72 | MEN1 (0.41) | CDK4CDK2CCNE1CDK9CDK1 | |
| SCHEMBL28059009 | 0.72 | MEN1 (0.46) | CDK4CDK2CCNE1CDK9CDK1 | |
| SCHEMBL1883531 | 0.70 | MAPK14 (0.45) | CDK4CDK2CCNE1PLK1MEN1 | |
| SCHEMBL8230360 | 0.70 | MAPT (0.42) | CDK4CDK2CCNE1CDK9CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | claimed |
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | disclosed |