Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CDK7 | P50613 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | CCNH | P51946 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059019 | 0.89 | PIK3CA (0.46) | MEN1KMT2ATDP1L3MBTL1NPC1 | |
| SCHEMBL28059057 | 0.78 | MAPT (0.55) | MEN1KMT2APOLBNPC1CCNT1 | |
| SCHEMBL5789745 | 0.76 | CDK4 (0.62) | MEN1KMT2AGAATDP1NPC1 | |
| SCHEMBL28059033 | 0.76 | SORT1 (0.44) | MEN1KMT2AGAAPOLBNPC1 | |
| SCHEMBL28059092 | 0.75 | MAPK14 (0.52) | MEN1KMT2AGAATDP1L3MBTL1 | |
| SCHEMBL28826932 | 0.72 | XIAP (0.47) | CCNT1CCNA2CDK2CDK9CDK4 | |
| SCHEMBL28059017 | 0.72 | CDK4 (0.64) | MEN1KMT2AGAATDP1NPC1 | |
| SCHEMBL28059001 | 0.72 | MAPK10 (0.61) | MEN1KMT2AGAATDP1POLB | |
| SCHEMBL28059002 | 0.71 | PIK3C3 (0.52) | MEN1KMT2ATDP1L3MBTL1NPC1 | |
| Morpholine SCHEMBL28059098 | 0.71 | MAPK10 (0.46) | MEN1KMT2AGAANPC1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | claimed |
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | disclosed |