Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | KMO | O15229 | 3/20 | 0.55 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM5A | P29375 | 3/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.49 |
| ▸ | ASPH | Q12797 | 2/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.49 |
| ▸ | KDM4A | O75164 | 2/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | TET3 | O43151 | 1/20 | 0.49 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30281319 | 0.91 | KDM4E (0.53) | KDM4ESMN1; SMN2L3MBTL1GLAHTT | |
| SCHEMBL21044780 | 0.91 | KDM4E (0.53) | KDM4ESMN1; SMN2L3MBTL1GLAHTT | |
| SCHEMBL19138214 | 0.84 | QDPR (0.46) | KDM4ESMN1; SMN2L3MBTL1GLAHTT | |
| SCHEMBL31705813 | 0.84 | KDM4E (0.46) | KDM4ESMN1; SMN2L3MBTL1GLAHTT | |
| SCHEMBL5214823 | 0.79 | HIF1A (0.57) | KDM4ESMN1; SMN2L3MBTL1GLAHTT | |
| SCHEMBL31706149 | 0.78 | TLR9 (0.48) | KDM4ESMN1; SMN2L3MBTL1GLAHTT | |
| SCHEMBL14876091 | 0.76 | SMN1; SMN2 (0.43) | KDM4ESMN1; SMN2L3MBTL1GLAHTT | |
| SCHEMBL31706609 | 0.76 | TLR9 (0.45) | KDM4ESMN1; SMN2ALDH1A1KDM5AKDM5B | |
| SCHEMBL27999883 | 0.76 | OPRM1 (0.45) | — | |
| SCHEMBL22402404 | 0.75 | CCNT1 (0.37) | KDM4ESMN1; SMN2L3MBTL1GLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541466-B2 | Tetrahydroisoquinoline derivatives for treating protein trafficking diseases | GENZYME CORPORATION (US) | 2009-06-02 | — | — | US | disclosed |
| US-20050176761-A1 | Tetrahydroisoquinoline derivatives for treating protein trafficking diseases | GENZYME CORPORATION (US) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176761-A1 | Tetrahydroisoquinoline derivatives for treating protein trafficking diseases | CFTR, NPC1L1, GOLT1B | KDM4E 4494/4885SMN1; SMN2 2673/4885L3MBTL1 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.