Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7592433 | 1.00 | ALDH1A1 (0.57) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Lysine SCHEMBL27396195 | 0.99 | ALDH1A1 (0.55) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Glutamic Acid SCHEMBL29993402 | 0.83 | ALDH1A1 (0.60) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Lysine SCHEMBL30844060 | 0.83 | GSR (0.61) | GSRGRM8GRM4NOS1POLB | |
| SCHEMBL717650 | 0.82 | GRM8 (0.49) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Isophthalic Acid SCHEMBL5947057 | 0.81 | GSR (0.62) | GSRGRM4POLBKMT2ATDP1 | |
| Niacin SCHEMBL10620476 | 0.81 | ALDH1A1 (0.66) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Isophthalic Acid SCHEMBL14343321 | 0.81 | GSR (0.62) | GSRGRM4POLBKMT2ATDP1 | |
| Lysine SCHEMBL11145520 | 0.81 | GSR (0.71) | GSRNOS1POLBKMT2ATDP1 | |
| Lysine SCHEMBL1066668 | 0.81 | GSR (0.71) | GSRNOS1POLBKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103805627-B | The method that disposable fermentation prepares high-purity lysine sulphate | 宁夏伊品生物科技股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-103451223-B | The method of high-purity lysine sulphate is prepared in disposable fermentation | NINGXIA EPPEN BIOTECH CO., LTD. (CN) | 2016-05-04 | — | — | CN | disclosed |