Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.63 |
| ▸ | BTK | Q06187 | 8/20 | 0.63 |
| ▸ | JAK3 | P52333 | 5/20 | 0.63 |
| ▸ | JAK2 | O60674 | 3/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059335 | 1.00 | EGFR (0.63) | EGFRBTKJAK3JAK2ERBB2 | |
| SCHEMBL28059271 | 0.88 | EGFR (0.63) | EGFRBTKJAK3JAK2 | |
| SCHEMBL28059273 | 0.87 | EGFR (0.54) | EGFRBTKJAK3JAK2 | |
| SCHEMBL28059334 | 0.84 | BTK (0.85) | EGFRBTKJAK3JAK2ERBB2 | |
| SCHEMBL12519708 | 0.81 | BTK (0.82) | EGFRBTKJAK3JAK2 | |
| SCHEMBL29722371 | 0.81 | BTK (0.82) | EGFRBTKJAK3JAK2 | |
| SCHEMBL26876001 | 0.79 | JAK3 (0.67) | EGFRJAK3JAK2 | |
| SCHEMBL18000712 | 0.79 | JAK3 (0.60) | EGFRBTKJAK3JAK2ERBB2 | |
| SCHEMBL18000900 | 0.79 | EGFR (0.66) | EGFRJAK3JAK2 | |
| SCHEMBL18970349 | 0.78 | EGFR (0.72) | EGFRBTKJAK3JAK2ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384695-A | Pyrimidine derivative, preparation method therefor and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |