Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.49 |
| ▸ | KCNA3 known ✓ | P22001 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979738 | 0.89 | CYP2D6 (0.58) | OPRM1CYP2D6DRD2DRD4DRD3 | |
| SCHEMBL27839435 | 0.79 | CYP2D6 (0.49) | OPRM1CYP2D6DRD2DRD4DRD3 | |
| SCHEMBL28218980 | 0.77 | DRD2 (0.54) | OPRM1CYP2D6DRD2DRD4DRD3 | |
| Phosphoric Acid SCHEMBL27373083 | 0.73 | PTPN1 (0.47) | CYP2D6PTPN1LMNACYP2C19 | |
| Phosphoric Acid SCHEMBL27396881 | 0.73 | PTPN1 (0.47) | CYP2D6PTPN1CYP2C19 | |
| Phosphoric Acid SCHEMBL28811988 | 0.73 | PTPN1 (0.47) | CYP2D6PTPN1LMNACYP2C19 | |
| Phosphoric Acid SCHEMBL27327780 | 0.73 | PTPN1 (0.47) | CYP2D6PTPN1LMNACYP2C19 | |
| SCHEMBL4014770 | 0.73 | DRD2 (0.65) | OPRM1CYP2D6DRD2DRD4DRD3 | |
| SCHEMBL2066381 | 0.72 | ATM (0.55) | OPRM1CYP2D6DRD2DRD4DRD3 | |
| SCHEMBL6435042 | 0.72 | KCNN4 (0.40) | OPRM1CYP2D6DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103319411-B | A kind of method preparing imidafenacin | SHAANXI BUCHANG HIGH-TECH PHARMACEUTICAL CO., LTD. (CN) | 2016-04-06 | — | — | CN | disclosed |