Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059505 | 1.00 | POLB (0.52) | POLBMAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL28059500 | 1.00 | POLB (0.52) | POLBMAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL28059388 | 0.98 | TSHR (0.51) | POLBMAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL28059464 | 0.93 | TSHR (0.57) | POLBMAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL13931342 | 0.84 | FFAR1 (0.56) | POLBMAPK1SMN1; SMN2ALDH1A1PPARA | |
| SCHEMBL4440034 | 0.82 | TNFRSF1A (0.52) | POLBMAPK1SMN1; SMN2ALDH1A1PPARA | |
| SCHEMBL4440040 | 0.82 | TNFRSF1A (0.52) | POLBMAPK1SMN1; SMN2ALDH1A1PPARA | |
| SCHEMBL8164075 | 0.81 | TSHR (0.59) | SMN1; SMN2TSHRALDH1A1PPARAFFAR4 | |
| SCHEMBL12432397 | 0.80 | ACHE (0.52) | ACHESYK | |
| SCHEMBL19463647 | 0.79 | TSHR (0.45) | TSHRALDH1A1PPARAFFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105418412-A | Hypoglycemic active compound and pharmaceutical application thereof | INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA | 2016-03-23 | — | — | CN | claimed |
| CN-105418412-A | Hypoglycemic active compound and pharmaceutical application thereof | INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA | 2016-03-23 | — | — | CN | disclosed |