SCHEMBL28059643

SCHEMBL28059643

CCOC(=O)C(NS(=O)(=O)c1ccc([N+](=O)[O-])cc1)C(=O)OCC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 5/20 0.52
MMP2 P08253 4/20 0.52
CA12 O43570 4/20 0.52
CA9 Q16790 4/20 0.52
CA14 Q9ULX7 3/20 0.52
MMP1 P03956 2/20 0.52
MMP9 P14780 2/20 0.52
MMP13 P45452 2/20 0.52
MMP3 P08254 1/20 0.52
MMP7 P09237 1/20 0.52
SLC1A3 P43003 1/20 0.51
SLC1A2 P43004 1/20 0.51
SLC1A1 P43005 1/20 0.51
CA1 P00915 4/20 0.50
KMT2A Q03164 3/20 0.50
MEN1 O00255 2/20 0.50
MMP8 P22894 1/20 0.50
CA3 P07451 1/20 0.50
CA4 P22748 1/20 0.50
CA6 P23280 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29196172 0.84 KMT2A (0.57) CA2MMP2CA12CA9CA14
SCHEMBL9594962 0.83 MMP2 (0.50) CA2MMP2CA12CA9CA14
SCHEMBL13405184 0.81 MMP2 (0.46) CA2MMP2CA12CA9CA14
SCHEMBL29196167 0.81 KMT2A (0.54) CA2MMP2CA12CA9CA14
SCHEMBL5134084 0.80 BACE1 (0.57) MMP2MMP9MAPTL3MBTL1ALDH1A1
SCHEMBL5041194 0.80 BACE1 (0.57) MMP2MMP9MAPTL3MBTL1ALDH1A1
SCHEMBL11853731 0.80 KMT2A (0.57) CA2MMP2CA12CA9CA14
SCHEMBL29196169 0.80 ALDH1A1 (0.58) CA2MMP2CA12CA9CA14
SCHEMBL3152558 0.78 KMT2A (0.62) CA2MMP2CA12CA9CA14
SCHEMBL22492367 0.78 ALDH1A1 (0.60) CA2MMP2CA12CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117924137-A Azetidine diester and preparation method and application thereof 南宁师范大学 2024-04-26 CN disclosed
CN-105481748-A 5-fluoro polysubstituted pyrroline derivative and preparation method thereof UNIV EAST CHINA NORMAL 2016-04-13 CN disclosed