Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 5/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25063332 | 0.76 | GAA (0.44) | KDM4ELMNAGLSCA1CA2 | |
| SCHEMBL28813639 | 0.75 | GLS (0.43) | KDM4ELMNAGLSCA1CA2 | |
| SCHEMBL10042081 | 0.74 | GLS (0.43) | KDM4ELMNAGLSCA1CA2 | |
| SCHEMBL15248092 | 0.74 | GLS (0.43) | KDM4ELMNAGLSCA1CA2 | |
| SCHEMBL15945413 | 0.73 | GLS (0.42) | KDM4ELMNAGLSCA1CA2 | |
| SCHEMBL11455539 | 0.73 | GLS (0.42) | KDM4ELMNAGLSCA1CA2 | |
| SCHEMBL8056438 | 0.73 | GLS (0.42) | KDM4ELMNAGLSCA1CA2 | |
| SCHEMBL18633046 | 0.72 | GLS (0.44) | KDM4ELMNAGLSCA1CA2 | |
| SCHEMBL18605522 | 0.71 | SMN1; SMN2 (0.50) | GLSMEN1GAAKMT2APOLB | |
| SCHEMBL15939915 | 0.68 | GLS (0.39) | KDM4ELMNAGLSCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917528-B | PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-04-20 | — | — | CN | disclosed |
| CN-103917528-A | Pyrimidine PDE10 inhibitors | MERCK SHARP & DOHME | 2014-07-09 | — | — | CN | disclosed |