Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18833426 | 1.00 | KDM4E (0.39) | KDM4ECA4MTNR1AMTNR1BLMNA | |
| SCHEMBL17707975 | 0.80 | ACHE (0.41) | LMNATSHRPOLBMEN1KMT2A | |
| SCHEMBL14463423 | 0.79 | ATM (0.40) | KDM4ECA4MTNR1AMTNR1BLMNA | |
| SCHEMBL11022205 | 0.79 | KDM4E (0.40) | KDM4ECA4MTNR1AMTNR1BLMNA | |
| SCHEMBL11911977 | 0.79 | ATM (0.40) | KDM4ECA4MTNR1AMTNR1BLMNA | |
| SCHEMBL8718949 | 0.79 | ATM (0.40) | KDM4ECA4MTNR1AMTNR1BLMNA | |
| SCHEMBL10941 | 0.78 | TDP1 (0.43) | KDM4EMAOAMAOBTSHRPOLB | |
| SCHEMBL2833080 | 0.78 | LDHA (0.42) | KDM4ELMNATSHRSLC6A4MEN1 | |
| SCHEMBL11238 | 0.78 | TDP1 (0.43) | KDM4EMAOAMAOBTSHRPOLB | |
| SCHEMBL11433 | 0.78 | TDP1 (0.43) | KDM4EMAOAMAOBTSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103930400-B | Prepare method and the intermediate of 1-acyl-4-phenyl alkylsulfonyl Prolinamide derivatives | HOFFMAN-LA ROCHE LTD. (CH) | 2016-04-20 | — | — | CN | disclosed |