Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304223 | 0.85 | MEN1 (1.00) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL19305858 | 0.82 | HTT (0.55) | MEN1KMT2AKDM4EHTTNPC1 | |
| SCHEMBL25752263 | 0.82 | HTT (0.55) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL6671752 | 0.82 | HTT (0.65) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL16518670 | 0.81 | MEN1 (0.84) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL14539624 | 0.77 | HTT (0.59) | KDM4EHTTMAPTGFERNPSR1 | |
| SCHEMBL27624091 | 0.76 | HTT (0.57) | KDM4EHTTMAPTGFERNPSR1 | |
| SCHEMBL666963 | 0.76 | HTT (0.57) | KDM4EHTTPKMMAPTGFER | |
| SCHEMBL20016685 | 0.75 | MEN1 (0.79) | MEN1KMT2AHTTNPC1RAB9A | |
| SCHEMBL27710911 | 0.75 | NPC1 (0.59) | KDM4EHTTNPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102725290-B | As the condensed heterocyclic compouds of ion channel modulators | GILEAD SCIENCES, INC. (US) | 2016-03-09 | — | — | CN | claimed |
| CN-102725290-B | As the condensed heterocyclic compouds of ion channel modulators | GILEAD SCIENCES, INC. (US) | 2016-03-09 | — | — | CN | disclosed |