SCHEMBL666963

SCHEMBL666963

CCC(=O)N(CC)c1cccnc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.57
CYP3A4 P08684 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2B6 P20813 1/20 0.52
CYP2C19 P33261 1/20 0.52
HDAC6 Q9UBN7 1/20 0.47
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 4/20 0.44
TSHR P16473 2/20 0.44
GLA P06280 1/20 0.44
NOTUM Q6P988 1/20 0.44
NPSR1 Q6W5P4 2/20 0.43
MAPT P10636 2/20 0.43
GFER P55789 1/20 0.43
TRPV1 Q8NER1 1/20 0.43
GAA P10253 1/20 0.42
NAPRT Q6XQN6 1/20 0.42
TRPM8 Q7Z2W7 1/20 0.42
KCNN4 O15554 1/20 0.41
KCNA5 P22460 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6671752 0.86 HTT (0.65) HTTCYP3A4CYP2C9CYP2B6CYP2C19
SCHEMBL14539624 0.85 HTT (0.59) HTTCYP3A4CYP2C9CYP2B6CYP2C19
SCHEMBL27624091 0.83 HTT (0.57) HTTCYP3A4CYP2C9CYP2B6CYP2C19
SCHEMBL4670467 0.83 HTT (0.54) HTTCYP3A4CYP2C9CYP2B6CYP2C19
SCHEMBL25629360 0.81 NOTUM (0.58) HTTCYP3A4CYP2C9CYP2B6CYP2C19
SCHEMBL19305858 0.81 HTT (0.55) HTTCYP3A4CYP2C9CYP2B6CYP2C19
SCHEMBL25752263 0.81 HTT (0.55) HTTCYP3A4CYP2C9CYP2B6CYP2C19
SCHEMBL2030599 0.78 ALDH1A1 (0.70) HTTALDH1A1TSHRGLAMAPT
SCHEMBL16432744 0.78 HTT (0.46) HTTCYP3A4CYP2C9CYP2B6CYP2C19
SCHEMBL12978259 0.77 HTT (0.66) HTTCYP3A4CYP2C9CYP2B6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10703754-B2 Compounds and compositions for treating chemical warfare agent-induced injuries ELI LILLY AND COMPANY (US) 2020-07-07 US disclosed
US-20190194202-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES ELI LILLY AND COMPANY 2019-06-27 US disclosed
US-20180265511-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES ELI LILLY AND COMPANY 2018-09-20 US disclosed
US-20180133170-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS ELI LILLY AND COMPANY 2018-05-17 US disclosed
WO-2015013835-A1 PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2015-02-05 WO disclosed
US-20130059869-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS HYDRA BIOSCIENCES, INC. 2013-03-07 US disclosed
US-20120046305-A1 METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISORDERS ELI LILLY AND COMPANY 2012-02-23 US disclosed
US-20090143377-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS ELI LILLY AND COMPANY 2009-06-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10703754-B2 Compounds and compositions for treating chemical warfare agent-induced injuries ELANE, CASP3, MMP8 HTT 4377/4885CYP3A4 2741/4885CYP2C9 1093/4885
US-20180133170-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS TRPA1, TRPV1, TRPV3 HTT 160/4885CYP3A4 2805/4885CYP2C9 2600/4885
US-20180265511-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES ELANE, CASP3, MMP8 HTT 4377/4885CYP3A4 2741/4885CYP2C9 1093/4885
US-20090143377-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS TRPA1, TRPV1, TRPV3 HTT 160/4885CYP3A4 2805/4885CYP2C9 2600/4885
US-20120046305-A1 METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISORDERS TRPA1, TRPV1, TRPV3 HTT 1239/4885CYP3A4 1812/4885CYP2C9 2213/4885
US-20190194202-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES ELANE, CASP3, MMP8 HTT 4377/4885CYP3A4 2741/4885CYP2C9 1093/4885
US-20130059869-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS TRPA1, TRPV1, TRPV3 HTT 160/4885CYP3A4 2805/4885CYP2C9 2600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.