Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25282701 | 0.90 | — | — | |
| SCHEMBL2084465 | 0.80 | DPP4 (0.41) | DPP4 | |
| SCHEMBL8629131 | 0.74 | — | — | |
| SCHEMBL3667120 | 0.74 | CYP2C19 (0.45) | MME | |
| SCHEMBL8630537 | 0.73 | CETP (0.30) | — | |
| SCHEMBL8625726 | 0.71 | CETP (0.33) | — | |
| SCHEMBL7409137 | 0.69 | MEN1 (0.37) | — | |
| SCHEMBL422018 | 0.67 | — | — | |
| SCHEMBL1488095 | 0.67 | — | — | |
| SCHEMBL16923652 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107158398-A | The MetAP2 inhibitor and its treatment method of application of polymeric conjugation | 辛德弗雷克斯公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-107141410-A | The MetAP2 inhibitor and its treatment method of application of polymeric conjugation | 辛德弗雷克斯公司 | 2017-09-08 | — | — | CN | disclosed |
| CN-103140512-B | Polymer-conjugated MetAP2 inhibitors and methods of treatment using the same | 辛德弗雷克斯公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-105431426-A | METAP2 inhibitors and methods of treating obesity | SYNDEVRX INC | 2016-03-23 | — | — | CN | disclosed |