SCHEMBL28061477

SCHEMBL28061477

CCCC(Br)c1ccsc1

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA4 P43681 1/20 0.36
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
ALOX5 P09917 1/20 0.35
DRD2 P14416 1/20 0.34
DRD3 P35462 1/20 0.34
SLC6A2 P23975 2/20 0.34
SLC6A4 P31645 2/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
SLC6A3 Q01959 1/20 0.34
KCNH2 Q12809 1/20 0.34
IDO1 P14902 1/20 0.33
TDO2 P48775 1/20 0.33
HTR1A P08908 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9315375 0.87 CHRNB2 (0.33) CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3
SCHEMBL28006225 0.85 LCK (0.34) CHRNB2CHRNB4CHRNA3CHRNA4ALOX5
SCHEMBL27728368 0.85 LCK (0.34) CHRNB2CHRNB4CHRNA3CHRNA4ALOX5
SCHEMBL27738392 0.85 LCK (0.34) CHRNB2CHRNB4CHRNA3CHRNA4ALOX5
SCHEMBL27738393 0.85 LCK (0.34) CHRNB2CHRNB4CHRNA3CHRNA4ALOX5
SCHEMBL1687703 0.78 ALOX5 (0.40) CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3
SCHEMBL27945530 0.77 ALOX5 (0.34) CHRNB2CHRNB4CHRNA3CHRNA4ALOX5
SCHEMBL18822219 0.76 ALOX5 (0.39) CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3
SCHEMBL13848615 0.76 CHRNB2 (0.36) CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3
SCHEMBL27818681 0.76 ALOX5 (0.39) CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111039847-B Magnolol derivative and preparation method and application thereof 深圳市老年医学研究所 2021-04-16 CN disclosed
CN-111039847-A Magnolol derivative and preparation method and application thereof 深圳市老年医学研究所 2020-04-21 CN disclosed
CN-103025729-B Transpirable organic semiconducting materials and the purposes in photoelectric cell thereof HELIATEK GMBH (DE) 2016-05-25 CN disclosed