Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28061549 | 0.77 | DRD2 (0.32) | SLC6A2SLC6A3LMNATHRBKMT2A | |
| SCHEMBL13739677 | 0.73 | CA12 (0.42) | KCNH2MAPTNOTUMPTGS2GAA | |
| SCHEMBL27483390 | 0.70 | TLR8 (0.36) | LMNATHRB | |
| SCHEMBL28531127 | 0.69 | CYP19A1 (0.42) | SLC6A4SLC6A2MAPTFNTAFNTB | |
| SCHEMBL7023638 | 0.67 | KMT2A (0.46) | MAPTLMNAPSEN1PSEN2APH1B | |
| SCHEMBL9560871 | 0.63 | HTR2A (0.41) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL1355763 | 0.63 | IDO1 (0.44) | MAPTLMNATHRBKDM4EALDH1A1 | |
| SCHEMBL1375267 | 0.63 | MAPT (0.42) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL4901152 | 0.63 | IDO1 (0.44) | MAPTLMNATHRBKDM4EALDH1A1 | |
| SCHEMBL11653814 | 0.62 | L3MBTL1 (0.46) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693645-A | FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS | 吉利德科学公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103649056-B | Fused heterocyclic compounds as modulators of ion channels | GILEAD SCIENCES, INC. (US) | 2016-04-27 | — | — | CN | disclosed |