Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | HTR2C | P28335 | 6/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28061558 | 1.00 | HTR2A (0.40) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL28061550 | 0.92 | HTR2C (0.42) | HTR2CHTR1A | |
| SCHEMBL8613370 | 0.84 | DDB1 (0.31) | — | |
| SCHEMBL28859930 | 0.73 | HTR2C (0.49) | HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL14660954 | 0.73 | HTR3A (0.46) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL14893971 | 0.72 | — | — | |
| SCHEMBL28061555 | 0.72 | JAK2 (0.37) | ADORA2A | |
| SCHEMBL16455098 | 0.71 | HTR2A (0.53) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL17046383 | 0.71 | DDB1 (0.31) | — | |
| SCHEMBL28061578 | 0.71 | JAK2 (0.34) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693645-B | Condensed heterocyclic compouds as ion channel modulators | 吉利德科学公司 | 2018-10-09 | — | — | CN | disclosed |
| CN-105693645-A | FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS | 吉利德科学公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103649056-B | Fused heterocyclic compounds as modulators of ion channels | GILEAD SCIENCES, INC. (US) | 2016-04-27 | — | — | CN | disclosed |