SCHEMBL28062820

SCHEMBL28062820

CCCO[Si](CCC)(CCC)c1ccc(Cl)cc1

nearest known ligand 0.32

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
NFKB1 P19838 1/20 0.32
CASP3 P42574 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
SENP8 Q96LD8 1/20 0.32
SENP7 Q9BQF6 1/20 0.32
SENP6 Q9GZR1 1/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
NR1I2 O75469 1/20 0.31
AHR P35869 1/20 0.31
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL705492 0.90 NR1H2 (0.33)
SCHEMBL28062938 0.89 SMN1; SMN2 (0.35) NPC1RAB9ASMN1; SMN2ALDH1A1LMNA
SCHEMBL17937667 0.89 SMN1; SMN2 (0.38) NPC1RAB9ASMN1; SMN2ALDH1A1LMNA
SCHEMBL17937680 0.87 ALDH1A1 (0.33) SMN1; SMN2ALDH1A1LMNANPSR1NR1I2
SCHEMBL28062834 0.87 SMN1; SMN2 (0.33) NPC1RAB9ASMN1; SMN2ALDH1A1LMNA
SCHEMBL17937674 0.82 SMN1; SMN2 (0.38) NPC1RAB9ASMN1; SMN2ALDH1A1LMNA
SCHEMBL28827560 0.81 MAPT (0.32) NPC1RAB9ASMN1; SMN2ALDH1A1LMNA
SCHEMBL17937715 0.81 POLB (0.33) SMN1; SMN2ALDH1A1LMNANR1I2AHR
SCHEMBL708502 0.81 LMNA (0.36) SMN1; SMN2ALDH1A1LMNAMEN1KMT2A
SCHEMBL28062796 0.80 KMT2A (0.37) ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105555901-A Polishing composition FUJIMI INC 2016-05-04 CN disclosed