Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.64 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.54 |
| ▸ | GRM5 | P41594 | 9/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805760 | 0.90 | PTGES (0.79) | PTGESPTGES2TRPV1 | |
| SCHEMBL981457 | 0.89 | PTGES (0.74) | PTGESGRM5P4HTM | |
| SCHEMBL2801520 | 0.84 | PTGES (0.58) | PTGESPTGES2TRPV1P4HTMEGLN1 | |
| SCHEMBL979893 | 0.82 | PTGES (0.57) | PTGESGRM5P4HTM | |
| SCHEMBL980273 | 0.82 | PTGES (0.74) | PTGESGRM5P4HTM | |
| SCHEMBL978649 | 0.82 | PTGES (0.60) | PTGESGRM5P4HTM | |
| SCHEMBL981304 | 0.81 | PTGES (0.56) | PTGESPTGES2GRM5P4HTM | |
| SCHEMBL976927 | 0.81 | PTGES (0.54) | PTGESPTGES2TRPV1EGLN1 | |
| SCHEMBL976823 | 0.79 | PTGES (1.00) | PTGES | |
| SCHEMBL2802193 | 0.79 | PTGES (0.83) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132016-A1 | BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | claimed |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | claimed |
| WO-2010132016-A1 | BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010132016-A1 | BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | PTGER1, SULT2A1, SULT1E1 | PTGES 9/4885PTGES2 24/4885GRM5 1655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.