Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577713 | 0.82 | PDE10A (0.44) | PDE10ACHRM4TRPV1CHRM2 | |
| SCHEMBL1557803 | 0.74 | HSD11B1 (0.35) | PDE10AMAPTALDH1A1GAARAB9A | |
| SCHEMBL6276568 | 0.74 | NPC1 (0.46) | PDE10AMAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL16673614 | 0.71 | CYP46A1 (0.46) | — | |
| SCHEMBL9988179 | 0.71 | PDE10A (0.64) | PDE10AALDH1A1HTTCHRM4TRPV1 | |
| SCHEMBL1303713 | 0.71 | PDE10A (0.39) | PDE10ARAB9ACYP2C9L3MBTL1TRPV1 | |
| SCHEMBL9984684 | 0.71 | PDE10A (0.39) | PDE10ACYP2C19TRPV1 | |
| SCHEMBL9988573 | 0.70 | PDE10A (0.43) | PDE10ACHRM4TRPV1CHRM2KMT2A | |
| SCHEMBL23755576 | 0.70 | PDE10A (0.36) | PDE10ACHRM4MAPK7 | |
| SCHEMBL2596306 | 0.70 | PDE10A (0.40) | PDE10ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473554-A | Fused piperidine amides as modulators of ion channels | VERTEX PHARMA | 2016-04-06 | — | — | CN | disclosed |