Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 6/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8036927 | 1.00 | GABRA1 (0.42) | GABRA1GABRB2ALDH1A1KDM4ENPC1 | |
| SCHEMBL9638056 | 0.82 | GABRA1 (0.48) | GABRA1GABRB2ALDH1A1KDM4ENPC1 | |
| SCHEMBL29974942 | 0.82 | GABRA1 (0.48) | GABRA1GABRB2ALDH1A1KDM4ENPC1 | |
| SCHEMBL13714257 | 0.79 | DHODH (0.37) | KDM4EDHODHIDO1HIF1ATDO2 | |
| SCHEMBL9940818 | 0.79 | ADRB2 (0.45) | ALDH1A1NPC1LMNAHPGDRAB9A | |
| SCHEMBL23579155 | 0.77 | KDM4E (0.44) | KDM4ENPC1LMNAHPGDHTT | |
| SCHEMBL29609179 | 0.77 | ADRB2 (0.46) | ALDH1A1NPC1HPGDRAB9ATSHR | |
| SCHEMBL29609167 | 0.77 | ADRB2 (0.46) | ALDH1A1NPC1HPGDRAB9ATSHR | |
| SCHEMBL29233079 | 0.77 | GABRA1 (0.52) | GABRA1GABRB2ALDH1A1KDM4ENPC1 | |
| SCHEMBL11373169 | 0.77 | GABRA1 (0.38) | GABRA1GABRB2ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541774-B | 3,4- dihydrocoumarin class compounds and its preparation method and application | 华中师范大学 | 2018-06-15 | — | — | CN | disclosed |
| CN-105541774-A | 3,4-dihydrocoumarin compound and preparation method and application thereof | UNIV HUAZHONG | 2016-05-04 | — | — | CN | disclosed |