Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.88 |
| ▸ | MEN1 | O00255 | 6/20 | 0.88 |
| ▸ | POLB | P06746 | 5/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.88 |
| ▸ | HTT | P42858 | 3/20 | 0.88 |
| ▸ | HPGD | P15428 | 2/20 | 0.88 |
| ▸ | NPY1R | P25929 | 1/20 | 0.88 |
| ▸ | GAA | P10253 | 6/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | RAD52 | P43351 | 2/20 | 0.60 |
| ▸ | IDE | P14735 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28064562 | 0.91 | KDM4E (0.73) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL28827974 | 0.90 | KDM4E (0.72) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL28064414 | 0.90 | ALDH1A1 (0.72) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL28064416 | 0.90 | KDM4E (0.72) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL15466789 | 0.78 | KMT2A (0.77) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL13248361 | 0.78 | KMT2A (0.73) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL28551149 | 0.76 | KDM4E (0.63) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL4726553 | 0.75 | NPSR1 (1.00) | KDM4EKMT2APOLBSMN1; SMN2LMNA | |
| SCHEMBL28064491 | 0.75 | KMT2A (0.72) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL28541749 | 0.74 | MAPK1 (0.60) | KDM4EALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105461723-B | Phthalazines simultaneously assimilation compound of [1,2, b] quinazoline 8 and preparation method thereof and the application in antineoplastic | 广西师范大学 | 2017-12-08 | — | — | CN | disclosed |
| CN-105461723-A | Phthalizine [1,2,b] quinazoline-8-ketone compound and preparation method and application in antitumor drugs of phthalizine [1,2,b] quinazoline-8-ketone compound | UNIV GUANGXI NORMAL | 2016-04-06 | — | — | CN | disclosed |