Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | MAP2 | P11137 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28064659 | 0.86 | MCL1 (0.50) | PRMT5MCL1KDM4ETSHRKMT2A | |
| SCHEMBL28064624 | 0.81 | BTK (0.42) | MCL1KDM4ETSHRL3MBTL1EGFR | |
| SCHEMBL6595214 | 0.73 | TSHR (0.64) | KDM4ETSHRKMT2AL3MBTL1PKM | |
| SCHEMBL35212204 | 0.73 | TSHR (0.64) | KDM4ETSHRKMT2AL3MBTL1PKM | |
| SCHEMBL28828000 | 0.73 | KDM4E (0.37) | KDM4ETSHRKMT2APOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28262758 | 0.72 | TSHR (0.62) | KDM4ETSHRKMT2AL3MBTL1PKM | |
| SCHEMBL28208613 | 0.70 | TSHR (0.51) | KDM4ETSHRKMT2APOLBSMN1; SMN2 | |
| SCHEMBL16381206 | 0.70 | FEN1 (0.49) | KDM4ETSHRL3MBTL1EGFRSRC | |
| SCHEMBL16571398 | 0.70 | GPR35 (0.36) | MCL1KMT2AL3MBTL1MAP2ALDH1A1 | |
| SCHEMBL16571676 | 0.69 | GRM2 (0.41) | L3MBTL1MAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555763-A | Indole-carboxamide derivatives | HOFFMANN LA ROCHE | 2016-05-04 | — | — | CN | disclosed |