Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28064501 | 0.86 | PRMT5 (0.41) | MCL1KDM4EL3MBTL1KMT2APRMT5 | |
| SCHEMBL28064638 | 0.81 | MCL1 (0.47) | MCL1GPR35FABP4RORCKDM4E | |
| SCHEMBL23809174 | 0.78 | MCL1 (0.45) | MCL1GPR35FABP4KDM4EL3MBTL1 | |
| SCHEMBL8692545 | 0.77 | GPR35 (0.42) | MCL1GPR35TSHRNOTUMUSP2 | |
| SCHEMBL24896372 | 0.75 | GPR35 (0.40) | MCL1GPR35FABP4KDM4EL3MBTL1 | |
| SCHEMBL19331295 | 0.74 | EGFR (0.45) | MCL1RORCKDM4EL3MBTL1DHODH | |
| SCHEMBL28828000 | 0.74 | KDM4E (0.37) | KDM4EKMT2ATSHRNOTUMLMNA | |
| SCHEMBL1092586 | 0.73 | KDM4E (0.67) | MCL1KDM4EL3MBTL1KMT2ATSHR | |
| SCHEMBL30639179 | 0.73 | KDM4E (0.67) | MCL1KDM4EL3MBTL1KMT2ATSHR | |
| SCHEMBL28792536 | 0.71 | HTR2C (0.47) | MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555763-A | Indole-carboxamide derivatives | HOFFMANN LA ROCHE | 2016-05-04 | — | — | CN | disclosed |