Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | TXNRD1 | Q16881 | 6/20 | 0.55 |
| ▸ | GSR | P00390 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28470144 | 0.90 | MEN1 (0.51) | MEN1RAB9AKMT2APAX8TXNRD1 | |
| SCHEMBL20471639 | 0.80 | TXNRD1 (0.47) | MEN1RAB9AKMT2APAX8TXNRD1 | |
| SCHEMBL21247456 | 0.80 | TXNRD1 (0.47) | MEN1RAB9AKMT2APAX8TXNRD1 | |
| SCHEMBL20471643 | 0.80 | TXNRD1 (0.47) | MEN1RAB9AKMT2APAX8TXNRD1 | |
| SCHEMBL28469727 | 0.78 | TXNRD1 (0.51) | PAX8TXNRD1POLBALDH1A1MAPT | |
| SCHEMBL20471646 | 0.78 | SMN1; SMN2 (0.49) | MEN1RAB9AKMT2APAX8TXNRD1 | |
| SCHEMBL2316143 | 0.77 | MEN1 (0.64) | MEN1RAB9AKMT2APAX8TXNRD1 | |
| SCHEMBL1491259 | 0.77 | MEN1 (0.64) | MEN1RAB9AKMT2APAX8TXNRD1 | |
| SCHEMBL390468 | 0.77 | MEN1 (0.64) | MEN1RAB9AKMT2APAX8TXNRD1 | |
| SCHEMBL392828 | 0.77 | MEN1 (0.64) | MEN1RAB9AKMT2APAX8TXNRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642838-B | EGFR inhibitor and preparation and application thereof | 江苏威凯尔医药科技有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-110642838-A | EGFR inhibitor and preparation and application thereof | 江苏威凯尔医药科技有限公司 | 2020-01-03 | — | — | CN | disclosed |
| CN-105503827-B | EGFR inhibitor and its preparation method and application | 上海翰森生物医药科技有限公司 | 2019-09-24 | — | — | CN | disclosed |
| CN-105503827-A | EGFR (Epidermal growth factor receptor) inhibitor and preparation method and use thereof | SHANGHAI HANSOH BIOMEDICAL CO LTD | 2016-04-20 | — | — | CN | disclosed |