Sugi Predict

Sugi Predict / Compounds / SCHEMBL392828

SCHEMBL392828

SCHEMBL392828

NS(=O)(=O)c1ncccc1[N+](=O)[O-]

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.64
▸ KMT2A Q03164 5/20 0.64
▸ RAB9A P51151 2/20 0.64
▸ PAX8 Q06710 1/20 0.60
▸ MAPT P10636 3/20 0.56
▸ PDE10A Q9Y233 1/20 0.50
▸ POLB P06746 1/20 0.49
▸ ALDH1A1 P00352 2/20 0.45
▸ LMNA P02545 2/20 0.45
▸ CYP1A2 P05177 2/20 0.45
▸ CYP2C9 P11712 2/20 0.45
▸ NCOA1 Q15788 1/20 0.45
▸ NCOA3 Q9Y6Q9 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ KDM4E B2RXH2 1/20 0.45
▸ NPC1 O15118 1/20 0.45
▸ BRD4 O60885 1/20 0.45
▸ CTSB P07858 1/20 0.45
▸ HSP90AA1 P07900 1/20 0.45
▸ CHRM1 P11229 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1491259 0.82 MEN1 (0.64) MEN1KMT2ARAB9APAX8MAPT
SCHEMBL390468 0.82 MEN1 (0.64) MEN1KMT2ARAB9APAX8MAPT
SCHEMBL2316143 0.82 MEN1 (0.64) MEN1KMT2ARAB9APAX8MAPT
SCHEMBL11107368 0.81 MEN1 (0.59) MEN1KMT2ARAB9APAX8MAPT
SCHEMBL20476787 0.81 KMT2A (0.71) MEN1KMT2ARAB9APAX8MAPT
Hydrochloric Acid SCHEMBL28105348 0.81 MEN1 (0.62) MEN1KMT2ARAB9APAX8MAPT
SCHEMBL25259337 0.78 PAX8 (0.60) MEN1KMT2ARAB9APAX8MAPT
SCHEMBL18497242 0.78 KMT2A (1.00) MEN1KMT2ARAB9APAX8MAPT
SCHEMBL28332934 0.78 MEN1 (0.59) MEN1KMT2ARAB9APAX8MAPT
SCHEMBL31193452 0.78 PAX8 (0.60) MEN1KMT2ARAB9APAX8MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078116-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2026-03-19 — — US disclosed
US-12414997-B2 Brush prodrugs and uses thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2025-09-16 — — US disclosed
CN-120129676-A Compounds, compositions, and methods thereof 海湃泰克(北京)生物医药科技有限公司 2025-06-10 — — CN disclosed
US-12268739-B2 Use of toll-like receptor 2 (TLR-2) agonist for modulating human immune response CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-04-08 — — US disclosed
CN-119451678-A Inhibition of histone deacetylase 6 (HDAC 6) 艾科尼佐治疗股份有限公司 2025-02-14 — — CN disclosed
CN-114746095-B HCK as therapeutic target of MYD88 mutant diseases 达纳-法伯癌症研究所有限公司 2025-01-24 — — CN disclosed
US-20250002637-A1 OXIME-BASED HOT MELT ADHESIVES FOR REWORK, REPAIR, AND RECYCLE CONAGEN INC. (US) 2025-01-02 — — US disclosed
CN-119212707-A Oxadiazole HDAC6 inhibitors and uses thereof 艾科尼佐治疗股份有限公司 2024-12-27 — — CN disclosed
CN-118973616-A Trkb ligand conjugated compounds and uses thereof 阿达尔克斯制药有限公司 2024-11-15 — — CN disclosed
US-20240301430-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES PHIO PHARMACEUTICALS CORP. (US) 2024-09-12 — — US disclosed
US-7939524-B2 5,6-dihydro-1H-pyridin-2-one compounds ANADYS PHARMACEUTICALS, INC. (US) 2011-05-10 — — US disclosed
CN-101677563-A 5, 6-dihydro-1H-pyridin-2-one compounds ANADYS PHARMACEUTICALS INC 2010-03-24 — — CN disclosed
US-20100034773-A1 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS ANADYS PHARMACEUTICALS, INC. (US) 2010-02-11 — — US disclosed
US-20100034773-A1 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS ANADYS PHARMACEUTICALS, INC. (US) 2010-02-11 — — US disclosed
EP-2129224-A1 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS Anadys Pharmaceuticals, Inc. (US) 2009-12-09 — — EP disclosed
WO-2008124450-A1 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS ANADYS PHARMACEUTICALS, INC. (US) 2008-10-16 — — WO disclosed
WO-2008124450-A1 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS ANADYS PHARMACEUTICALS, INC. (US) 2008-10-16 — — WO disclosed
EP-0735025-B1 Process for producing aminonitropyridines SUMITOMO CHEMICAL CO (JP) 1998-07-01 — — EP disclosed
US-5648496-A AMINATION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-07-15 — — US disclosed
EP-0735025-A1 Process for producing aminonitropyridines SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-10-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100034773-A1 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS HAVCR2, PYGL, HCCS MEN1 2830/4885KMT2A 4654/4885RAB9A 2493/4885
US-20240301430-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES CD2, CD74, IGSF11 MEN1 4700/4885KMT2A 820/4885RAB9A 4573/4885
US-20260078116-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS MYC, KRAS, MCL1 MEN1 1248/4885KMT2A 2402/4885RAB9A 562/4885
US-12414997-B2 Brush prodrugs and uses thereof ABCB11, SI, ABCB1 MEN1 420/4885KMT2A 2639/4885RAB9A 2169/4885
US-12268739-B2 Use of toll-like receptor 2 (TLR-2) agonist for modulating human immune response TLR2, TLR1, TLR3 MEN1 4791/4885KMT2A 2900/4885RAB9A 2794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.