Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 12/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28064896 | 0.80 | RIPK1 (0.48) | RIPK1ACHEPDE5AHRH3 | |
| SCHEMBL28209962 | 0.80 | RIPK1 (0.48) | RIPK1ACHEPDE5AHRH3 | |
| SCHEMBL19446182 | 0.79 | NR1H2 (0.45) | RIPK1 | |
| SCHEMBL17782283 | 0.79 | NR1H2 (0.45) | RIPK1 | |
| SCHEMBL17782285 | 0.79 | NR1H2 (0.45) | RIPK1 | |
| SCHEMBL16401244 | 0.76 | USP30 (0.39) | RIPK1USP30HHAT | |
| SCHEMBL28065088 | 0.73 | RIPK1 (0.41) | RIPK1ACHEPDE5AHRH3 | |
| SCHEMBL28065013 | 0.72 | HSD17B10 (0.36) | RIPK1 | |
| SCHEMBL27626761 | 0.72 | RIPK1 (0.47) | RIPK1PDE5A | |
| SCHEMBL28027168 | 0.71 | GRM5 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579444-B | Piperidinylindole derivatives and their use as complement factor B inhibitors | 诺华股份有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-105579444-A | Piperidinylindole derivatives and their use as complement factor B inhibitors | NOVARTIS AG | 2016-05-11 | — | — | CN | disclosed |