Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6814371 | 0.95 | CA1 (0.52) | CA1CA2MAPK1ACE2CYP3A4 | |
| Bicarbonate SCHEMBL9619217 | 0.88 | CA1 (0.54) | CA1CA2MAPK1CYP3A4TSHR | |
| Bicarbonate SCHEMBL7572929 | 0.86 | CA1 (0.54) | CA1CA2MAPK1ACE2GPR84 | |
| Acetic Acid SCHEMBL10943012 | 0.86 | CA1 (0.52) | CA1CA2MAPK1CYP3A4TSHR | |
| Acetic Acid SCHEMBL27695161 | 0.84 | CA1 (0.47) | CA1CA2MAPK1SLC1A3SLC1A2 | |
| Propionic Acid SCHEMBL2370939 | 0.84 | CA2 (0.50) | CA1CA2MAPK1CYP3A4TSHR | |
| Sulfuric Acid SCHEMBL28243103 | 0.80 | TP53 (0.50) | CA1CA2MAPK1SLC1A3SLC1A2 | |
| SCHEMBL626822 | 0.80 | CA2 (0.48) | CA1CA2MAPK1SLC15A1CYP3A4 | |
| Acrylic Acid SCHEMBL27681921 | 0.78 | CA1 (0.45) | CA1CA2MAPK1ACE2CYP3A4 | |
| Phosphine SCHEMBL27975608 | 0.78 | CA2 (0.47) | CA1CA2MAPK1SLC15A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458945-A | Process for preparing alkanolamines useful in removal of acid-gas from a gaseous stream | 贝尔法斯特女王大学 | 2017-02-22 | — | — | CN | claimed |
| CN-105593219-A | Glycidol preparation | THE QUEEN'S UNIV OF BELFAST | 2016-05-18 | — | — | CN | disclosed |