Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 7/20 | 1.00 |
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | MET | P08581 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | MGAM | O43451 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | SI | P14410 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | PON1 | P27169 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.51 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211418 | 0.86 | MCL1 (0.75) | MCL1MAOBMETGAAKDM4E | |
| SCHEMBL14898335 | 0.85 | MCL1 (0.77) | MCL1MAOBMETGAAKDM4E | |
| SCHEMBL876286 | 0.84 | MCL1 (0.73) | MCL1MAOBGAAKDM4EALDH1A1 | |
| SCHEMBL14898333 | 0.83 | MCL1 (0.77) | MCL1MAOBMETGAAKDM4E | |
| SCHEMBL15295521 | 0.81 | MCL1 (0.70) | MCL1MAOBMETGAAKDM4E | |
| SCHEMBL2791540 | 0.81 | MCL1 (0.70) | MCL1MAOBMETGAAKDM4E | |
| SCHEMBL15211432 | 0.81 | MCL1 (0.68) | MCL1MAOBGAAKDM4EALDH1A1 | |
| SCHEMBL18920869 | 0.80 | MAOB (1.00) | MCL1MAOBMETGAAKDM4E | |
| SCHEMBL15211319 | 0.80 | MCL1 (0.66) | MCL1MAOBGAAKDM4EALDH1A1 | |
| SCHEMBL5351976 | 0.79 | MET (1.00) | MCL1MAOBMETGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105524034-B | Preparation, pharmacological action and the application for treating cerebral ischemia of coumarin derivative | 北京大学 | 2018-08-17 | — | — | CN | disclosed |
| CN-105566269-B | Preparation, pharmacological action and the application for treating itch of coumarin derivative | 北京大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-105566269-A | Preparation and pharmacological effects of coumarin derivative and application of coumarin derivative to treatment on pruritus | UNIV BEIJING | 2016-05-11 | — | — | CN | disclosed |
| CN-105524034-A | Preparation method of coumarin derivative, pharmacological effect of coumarin derivative and use of coumarin derivative in treatment on cerebral ischemia | UNIV BEIJING | 2016-04-27 | — | — | CN | disclosed |