Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | PLK1 | P53350 | 4/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310055 | 0.85 | SUV39H2 (0.45) | EGFRPLK1ALKSUV39H2AURKA | |
| SCHEMBL29661369 | 0.85 | SUV39H2 (0.45) | EGFRPLK1ALKSUV39H2AURKA | |
| Hydrochloric Acid SCHEMBL29367159 | 0.84 | SUV39H2 (0.44) | EGFRPLK1ALKSUV39H2AURKA | |
| SCHEMBL10206636 | 0.79 | ALK (0.44) | EGFRPLK1ALKSUV39H2AURKA | |
| SCHEMBL14240636 | 0.78 | NTSR1 (0.47) | ALKSUV39H2INSRIGF1R | |
| SCHEMBL520746 | 0.78 | NTSR1 (0.47) | ALKSUV39H2INSRIGF1R | |
| SCHEMBL24603026 | 0.76 | SUV39H2 (0.45) | EGFRPLK1ALKSUV39H2AURKA | |
| SCHEMBL1783282 | 0.75 | MAPT (0.45) | EGFRPLK1ALKSUV39H2AURKA | |
| SCHEMBL3132203 | 0.75 | ACVR1 (0.45) | EGFRALKSUV39H2AURKAINSR | |
| SCHEMBL10206172 | 0.74 | ACVR1 (0.43) | SUV39H2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683168-B | Fragrant amino pyrimidines and its application and pharmaceutical composition prepared therefrom and Pharmaceutical composition | 上海海雁医药科技有限公司 | 2017-12-08 | — | — | CN | disclosed |
| CN-105683168-A | Arylamino pyramidine compound and application thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom | 上海海雁医药科技有限公司 | 2016-06-15 | — | — | CN | disclosed |