Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | ATM | Q13315 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21428259 | 0.85 | NPC1 (0.66) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL7195193 | 0.85 | NPC1 (0.66) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL496860 | 0.81 | NPC1 (0.60) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL28837908 | 0.81 | NPC1 (0.60) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL359176 | 0.81 | NPC1 (0.60) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL29953906 | 0.81 | NPC1 (0.60) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL30718798 | 0.81 | NPC1 (0.60) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL28864707 | 0.81 | NPC1 (0.60) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL8528387 | 0.80 | NPC1 (0.55) | NPC1MAPTRAB9AATMMEN1 | |
| SCHEMBL27765162 | 0.79 | NPC1 (0.58) | NPC1MAPTRAB9AATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007125-B | fused heterocyclic derivatives and methods of use | AMGEN INC. (US) | 2016-05-25 | — | — | CN | disclosed |