SCHEMBL28065890

SCHEMBL28065890

COc1cc(Cc2cccc3c2C=CC3)cc(OC)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 2/20 0.50
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
ABCB1 P08183 3/20 0.36
CHRM2 P08172 1/20 0.35
CHRM1 P11229 1/20 0.35
CHRM3 P20309 1/20 0.35
CNR1 P21554 1/20 0.34
GPR55 Q9Y2T6 1/20 0.34
PTGER4 P35408 2/20 0.34
PTGER2 P43116 2/20 0.34
CYP1A1 P04798 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2E1 P05181 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C8 P10632 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2A6 P11509 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP4B1 P13584 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189551 0.78 CA1 (0.32)
SCHEMBL6745352 0.77 ABCB1 (0.45) CALM1MEN1KMT2AABCB1PTGER4
SCHEMBL6912710 0.71 GABRA1 (0.40) CYP2D6
SCHEMBL6745346 0.71 TAAR1 (0.47) ABCB1CHRM2CHRM1CHRM3IDO1
SCHEMBL7195818 0.70 CA1 (0.32)
SCHEMBL6909824 0.68 DAO (0.31)
SCHEMBL23854835 0.68 CA1 (0.30)
SCHEMBL5698296 0.68 CA1 (0.30)
SCHEMBL21439260 0.68 PNMT (0.42)
SCHEMBL7333093 0.68 CA12 (0.41) CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105579438-A Compounds and methods for skin repair ALLERGAN INC 2016-05-11 CN disclosed